Plain-English answers
The GLP-1 questions everyone is actually asking.
Your one-stop guide to GLP-1 peptides — news, dosing tools, and plain-English answers to the questions everyone is actually asking.
Educational content. Not medical advice.
15%
Body weight reduction
Semaglutide STEP-1 trial
22%
Body weight reduction
Tirzepatide SURMOUNT-1 trial
24%
Body weight reduction
Retatrutide TRIUMPH-3 trial
Most asked
Quick answers
Can you get pregnant while taking a GLP-1?
GLP-1 use during pregnancy isn't recommended. Manufacturers advise stopping at least 2 months before conception. Surprise pregnancies on these drugs are real.
How long can semaglutide stay out of the refrigerator?
Once in use, an Ozempic or Wegovy pen is good for 56 days at room temperature (under 86°F). Unused pens must stay refrigerated. The full storage rules.
How do I titrate semaglutide?
The standard semaglutide titration schedule starts at 0.25 mg weekly and increases every 4 weeks. Here's why the ramp matters and what to do if side effects derail you.
From the blog
Go deeper
Why Your GLP-1 Weight Loss Plateaued (And What to Try)
Plateaus on Ozempic, Wegovy, or Zepbound are normal — and almost always solvable. Here's what causes them and the playbook that actually works.
What to Eat on GLP-1s When You Have No Appetite
Your appetite is gone but your body still needs protein, fiber, and nutrients. The eating playbook for Ozempic, Wegovy, and Zepbound users.
What Are GLP-1 Peptides? A Plain-English Guide
GLP-1 peptides like semaglutide and tirzepatide are reshaping weight loss and metabolic health. What they are, how they work, and what to know before starting.
Peptide news
What's happening now
FDA Posts Liver Failure Report Linked to Lilly's Foundayo
A single liver failure case in the FDA adverse event database briefly knocked Lilly stock; analysts and Lilly say one report is not a safety signal.
Mounjaro Dethrones Keytruda as World's Top-Selling Drug
Eli Lilly's tirzepatide franchise pulled in $36.5B in 2025, edging past Merck's Keytruda — the first time a GLP-1 has held the global No. 1 sales spot.